pharmacology topics for research paper

Pharmacology Research Paper Topics

In this page on pharmacology research paper topics , we explore the diverse and dynamic field of pharmacology and provide valuable resources for students who are tasked with writing research papers in this discipline. Pharmacology, as a branch of science, encompasses the study of how drugs interact with biological systems, aiming to understand their mechanisms of action, therapeutic uses, and potential side effects. With the growing importance of pharmacology in healthcare and drug development, it is crucial for students to delve into relevant pharmacology research paper topics that contribute to advancing knowledge and addressing current challenges in the field. Additionally, we highlight iResearchNet’s writing services, offering students the opportunity to order custom pharmacology research papers tailored to their specific needs. Our team of expert writers, equipped with in-depth knowledge of pharmacology and related fields, ensures high-quality, well-researched papers that adhere to the highest academic standards.

In the field of pharmacology, research plays a critical role in advancing our understanding of drugs, their mechanisms of action, and their impact on human health. As students of pharmacology, you may be tasked with writing research papers that explore various aspects of this dynamic discipline. To assist you in your research journey, we have curated a comprehensive list of pharmacology research paper topics that cover a wide range of subfields and emerging areas of interest. Whether you are interested in drug discovery, clinical pharmacology, pharmacogenomics, or drug safety, this list provides a wealth of ideas to inspire and guide your research endeavors.

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Drug Discovery and Development

• Role of Artificial Intelligence in Drug Discovery
• Personalized Medicine: Tailoring Drug Therapy to Individual Patients
• Drug Repurposing: Exploring New Indications for Existing Drugs
• Pharmacogenomics and Drug Response Prediction
• Nanomedicine: Applications in Drug Delivery and Targeting
• Innovative Approaches for Drug Formulation and Delivery
• Drug Combinations: Synergistic Effects and Therapeutic Opportunities
• Natural Products as Sources of Novel Therapeutic Agents
• Virtual Screening and Molecular Docking in Drug Design
• Pharmacokinetics and Pharmacodynamics of New Drug Entities

Clinical Pharmacology

• Precision Dosing: Optimizing Drug Therapy for Individual Patients
• Pharmacokinetic Variability in Special Populations (Pediatrics, Geriatrics, Pregnant Women)
• Drug-Drug Interactions: Mechanisms and Clinical Implications
• Adverse Drug Reactions: Identification, Prevention, and Management
• Pharmacovigilance and Drug Safety Monitoring
• Therapeutic Drug Monitoring: Rationale and Practical Considerations
• Clinical Trials in Pharmacology: Design, Implementation, and Analysis
• Drug Development and Regulatory Approval Processes
• Pharmacoeconomics: Evaluating the Cost-Effectiveness of Drug Therapy
• Ethical Considerations in Clinical Pharmacology Research

Neuropharmacology and Psychopharmacology

• Mechanisms of Action and Therapeutic Applications of Antidepressant Drugs
• Neurotransmitter Systems and Their Role in Mental Health Disorders
• Psychotropic Drugs and Their Impact on Cognitive Functioning
• Novel Approaches for Targeting Neurodegenerative Disorders
• Pharmacological Management of Substance Use Disorders
• Pharmacogenetics in Psychiatry: Implications for Individualized Treatment
• Role of Neuroinflammation in Neurological and Psychiatric Disorders
• Neuropharmacology of Sleep and Wakefulness
• Pharmacotherapy for Schizophrenia: Current Trends and Future Directions
• Novel Treatments for Anxiety and Mood Disorders

Pharmacokinetics and Drug Metabolism

• Drug Transporters and Their Role in Drug Disposition
• Pharmacogenetics and Personalized Drug Therapy
• Pharmacokinetic Variability and Its Impact on Drug Response
• Drug Metabolism Pathways and Enzyme Polymorphisms
• Drug-Drug Interactions: Mechanisms and Clinical Significance
• Predictive Modeling in Pharmacokinetics and Dose Optimization
• Pharmacokinetics in Special Populations: Pediatrics and Geriatrics
• Impact of Genetic Variation on Drug Clearance and Toxicity
• Role of Pharmacokinetics in Individualizing Drug Dosage
• Strategies for Improving Oral Bioavailability of Drugs

Pharmacology of Infectious Diseases

• Antimicrobial Resistance: Mechanisms, Epidemiology, and Strategies
• Development of Novel Antiviral Agents: Challenges and Opportunities
• Pharmacotherapy for Bacterial Infections: Current Approaches and Future Directions
• Antifungal Drugs: Mechanisms of Action and Resistance
• Host-Pathogen Interactions and Their Implications for Drug Development
• Pharmacokinetic Considerations in the Treatment of Viral Infections
• Targeting Virulence Factors in Bacterial Pathogens
• Drug Combination Therapy for Multidrug-Resistant Infections
• Pharmacogenomics of Antimicrobial Agents
• New Approaches for Antiparasitic Drug Development

Cardiovascular Pharmacology

• Novel Antiplatelet Agents: Mechanisms and Clinical Applications
• Antihypertensive Therapy: Current Strategies and Future Perspectives
• Pharmacotherapy for Heart Failure: Advancements and Challenges
• Role of Pharmacogenomics in Cardiovascular Drug Therapy
• Therapeutic Potential of Antiarrhythmic Agents
• Pharmacological Management of Dyslipidemia and Atherosclerosis
• Emerging Therapies for Pulmonary Hypertension
• Pharmacological Approaches to Preventing Thromboembolic Disorders
• Cardiotoxicity of Chemotherapeutic Agents: Mechanisms and Cardioprotective Strategies
• Targeting Inflammatory Pathways in Cardiovascular Disease

Pharmacology and Aging

• Geriatric Pharmacotherapy: Challenges and Approaches
• Age-Related Changes in Pharmacokinetics and Pharmacodynamics
• Polypharmacy and Its Impact on Older Adults
• Adverse Drug Reactions in the Elderly: Recognition and Prevention
• Pharmacological Management of Age-Related Neurodegenerative Disorders
• Geriatric Pharmacogenomics: Implications for Personalized Medicine
• Drug-Related Falls and Fractures in the Elderly: Prevention and Intervention
• Medication Adherence in Older Adults: Barriers and Strategies
• Geriatric Pain Management: Balancing Efficacy and Safety
• Optimizing Drug Therapy in Older Adults with Multiple Comorbidities

Pharmacology of Cancer

• Targeted Therapies for Solid Tumors: Recent Advances and Future Directions
• Immunotherapy in Cancer Treatment: Current Approaches and Challenges
• Pharmacogenomics of Chemotherapy: Implications for Personalized Treatment
• Drug Resistance in Cancer: Mechanisms and Strategies for Overcoming Resistance
• Pharmacokinetics and Pharmacodynamics of Anticancer Agents
• Combination Therapies in Oncology: Rationale and Clinical Outcomes
• Oncolytic Viruses: Exploiting Viral Infections for Cancer Treatment
• Cancer Stem Cells: Targeting Tumor Initiation and Progression
• Development of Novel Imaging Agents for Cancer Diagnosis and Monitoring
• Pharmacological Interventions for Cancer-Associated Pain Management

Pharmacology and Immunology

• Immune Checkpoint Inhibitors in Cancer Immunotherapy
• Autoimmune Diseases: Novel Pharmacological Approaches and Therapies
• Immunomodulatory Effects of Drugs: Implications for Therapeutic Interventions
• Role of Pharmacogenomics in Immunomodulatory Drug Therapy
• Immunopharmacology of Allergic Reactions: Mechanisms and Treatment Strategies
• Immunosuppressive Drugs in Transplantation: Balancing Efficacy and Safety
• Targeting Inflammatory Pathways in Autoimmune Disorders
• Immunopharmacological Interventions for Infectious Diseases
• Pharmacological Modulation of Cytokines in Inflammatory Disorders
• Vaccines: Advancements in Development and Delivery

Pharmacovigilance and Drug Safety

• Post-Marketing Surveillance: Detecting and Evaluating Adverse Drug Reactions
• Signal Detection in Pharmacovigilance: Methods and Applications
• Risk Management Strategies in Drug Development and Marketing
• Pharmacogenomic Biomarkers for Predicting Drug Safety
• Pharmacovigilance in Special Populations: Pregnant Women and Pediatrics
• Drug Safety Communication: Enhancing Patient Awareness and Education
• Role of Pharmacovigilance in Drug Regulatory Affairs
• Pharmacovigilance Data Mining: Leveraging Big Data for Drug Safety
• Pharmacovigilance Systems and Reporting Structures
• Pharmacogenetic Testing in Drug Safety Assessment

This comprehensive list of pharmacology research paper topics provides a broad range of ideas and areas to explore within the field of pharmacology. From drug discovery and development to clinical pharmacology, neuropharmacology, and pharmacokinetics, each category offers multiple topics for students to delve into and contribute to the advancement of pharmacological knowledge. Whether you are interested in the impact of pharmacogenomics on drug therapy, exploring novel treatment strategies, or investigating drug safety and pharmacovigilance, there is a wealth of research possibilities awaiting exploration. By selecting a topic of interest and following the expert advice on topic selection and research paper writing, students can embark on an enriching journey of discovery and make meaningful contributions to the field of pharmacology.

Pharmacology: Exploring the Range of Research Paper Topics

Pharmacology is a captivating and dynamic scientific discipline that focuses on the study of drugs and their effects on living organisms. It plays a crucial role in improving human health by advancing our understanding of how medications interact with biological systems. Within the field of pharmacology, there is a vast array of pharmacology research paper topics that offer students an opportunity to delve into various aspects of drug discovery, development, clinical application, and safety. In this article, we will explore the breadth and depth of pharmacology as a scientific field, highlighting the range of research paper topics it encompasses.

Drug Discovery and Development:  One exciting area of pharmacology research is drug discovery and development. This field involves the identification and development of new therapeutic agents to treat a wide range of diseases. Students interested in this area can explore topics such as the exploration of novel drug targets and therapeutic approaches, investigating natural products for drug development, advancements in targeted drug delivery systems, pharmacokinetics and pharmacodynamics of new drug entities, and understanding and overcoming drug resistance mechanisms.

Clinical Pharmacology:  Clinical pharmacology focuses on the application of pharmacological principles in the clinical setting. It plays a vital role in optimizing drug therapy and ensuring patient safety. Pharmacology research paper topics in this area may include pharmacogenomics, which explores the relationship between an individual’s genetic makeup and their response to medication. Other topics of interest include the identification, prevention, and management of adverse drug reactions, the design and ethical considerations in clinical trials, pharmacovigilance, and optimizing drug regimens for special populations such as pediatrics, geriatrics, and pregnant women.

Neuropharmacology and Psychopharmacology:  The field of neuropharmacology examines how drugs interact with the central nervous system and influence brain function. Pharmacology research paper topics in this area may involve investigating the mechanisms of action and therapeutic applications of psychotropic drugs, exploring neurotransmitter systems and their role in neurological disorders, pharmacological interventions for Alzheimer’s disease and other neurodegenerative disorders, the psychopharmacology of substance use disorders, and the pharmacological management of mental health disorders.

Pharmacokinetics and Drug Metabolism:  Pharmacokinetics and drug metabolism focus on understanding how drugs are absorbed, distributed, metabolized, and eliminated by the body. Pharmacology research paper topics in this area may include studying drug interactions, such as the mechanisms, predictions, and clinical implications of drug-drug interactions. Other topics of interest include pharmacogenetics and individual variations in drug response, the role of drug transporters in drug disposition, drug metabolism and its impact on drug-drug interactions, and the use of predictive modeling in pharmacokinetics and dosing optimization.

Pharmacology of Infectious Diseases:  The pharmacology of infectious diseases involves studying how drugs can effectively treat and prevent infections. Research topics in this area may include exploring antimicrobial resistance, including its mechanisms, epidemiology, and strategies to combat it. Additionally, students may investigate the development of new antiviral agents, the pharmacological management of bacterial infections, host-pathogen interactions, and the pharmacokinetic considerations in the treatment of infectious diseases.

Cardiovascular Pharmacology:  Cardiovascular pharmacology focuses on understanding the effects of drugs on the cardiovascular system. Research topics in this area may include exploring drug therapy for hypertension and current guidelines for treatment, novel anticoagulants in the prevention and treatment of thromboembolic disorders, pharmacological approaches to managing heart failure, drug-induced cardiotoxicity and strategies for prevention, and emerging pharmacotherapies for atherosclerosis and coronary artery disease.

Pharmacology and Aging:  Pharmacology and aging is a specialized field that investigates how drug therapy can be optimized in older adults. Research topics in this area may include exploring geriatric pharmacotherapy, age-related changes in pharmacokinetics and pharmacodynamics, the impact of polypharmacy on older adults, the recognition and prevention of adverse drug reactions, pharmacological management of age-related neurodegenerative disorders, and strategies for improving medication adherence in the elderly.

The field of pharmacology offers a wide range of exciting research paper topics that span from drug discovery and development to clinical pharmacology, neuropharmacology, pharmacokinetics, and beyond. By exploring these topics, students can contribute to the advancement of pharmacological knowledge and make meaningful contributions to the field. Remember to choose a research topic that aligns with your interests and career aspirations, and be sure to consult with your instructors or mentors for guidance throughout your research journey. With dedication, curiosity, and a passion for improving patient care, you have the opportunity to shape the future of pharmacology research.

How to Choose a Pharmacology Research Topic

Choosing the right research paper topic is crucial for a successful academic journey in pharmacology. It allows you to explore your interests, contribute to the field, and showcase your knowledge and skills. However, with the vast scope of pharmacology, selecting a research topic can be a daunting task. In this section, we will provide you with expert advice on how to choose pharmacology research paper topics that are engaging, relevant, and have the potential for significant contribution.

• Identify Your Interests : Start by identifying your areas of interest within pharmacology. Reflect on the topics that have captivated your attention during your coursework or sparked your curiosity. Consider whether you are more inclined towards drug discovery, clinical applications, pharmacokinetics, neuropharmacology, or any other subfield of pharmacology. This self-reflection will help you narrow down your options and select a topic that resonates with your passion.
• Stay Updated with Current Research : To choose a compelling research topic, it is essential to stay updated with the latest advancements and trends in pharmacology. Follow reputable scientific journals, attend conferences, and engage with the pharmacological community to gain insights into the ongoing research and emerging areas of interest. This will help you identify gaps in the current knowledge and select a topic that offers the potential for novel discoveries or addressing existing challenges.
• Consult with Faculty and Experts : Seek guidance from your faculty members, mentors, or experts in the field of pharmacology. They can provide valuable insights and suggest potential research areas based on their expertise and experience. Discuss your interests, goals, and research aspirations with them, and they can help you refine your research topic, provide relevant literature references, and offer valuable advice on the feasibility and scope of your chosen topic.
• Consider Practicality and Resources : When selecting a research topic, consider the practicality and availability of resources. Assess whether the necessary laboratory facilities, equipment, or access to clinical data are readily accessible to conduct your research. Additionally, consider the time and resources required to complete the research within the given timeframe. Choosing a topic that aligns with the available resources will enhance the feasibility and success of your research endeavor.
• Address Current Challenges or Gaps : Pharmacology is a field that constantly evolves, presenting new challenges and unanswered questions. Consider selecting a research topic that addresses current challenges or explores gaps in the existing knowledge. This could involve investigating the mechanisms of drug resistance, exploring novel drug targets, or optimizing drug regimens for specific patient populations. By tackling these challenges, you can contribute to the advancement of pharmacological science and make a meaningful impact.
• Collaborate with Peers : Consider collaborating with fellow students or researchers who share similar research interests. Collaborative research projects can provide a broader perspective, foster knowledge sharing, and enhance the overall quality of your research. Collaborating with peers also allows you to divide the workload, share resources, and receive feedback and support throughout the research process.
• Seek Ethical Considerations : When selecting a pharmacology research topic, it is essential to consider ethical considerations and adhere to the principles of research ethics. Ensure that your chosen topic respects patient confidentiality, follows the guidelines for the ethical use of animal subjects (if applicable), and aligns with the ethical principles outlined by regulatory bodies. Consulting with your institution’s ethics committee or research advisor can help ensure that your research project meets the required ethical standards.
• Evaluate Feasibility and Novelty : Evaluate the feasibility and novelty of your chosen research topic. Consider whether the research question is answerable within the available resources and time constraints. Additionally, assess whether your topic brings something new to the field, whether it fills a knowledge gap, or offers a fresh perspective on an existing topic. A balance between feasibility and novelty is essential for a successful research paper.
• Consult Literature Reviews : Conduct thorough literature reviews on your chosen topic to gain a comprehensive understanding of the existing research. Literature reviews help you identify gaps in the current knowledge and provide a foundation for your research question. They also enable you to build on previous findings, develop a robust research methodology, and position your research within the context of the broader field of pharmacology.
• Remain Flexible : Lastly, remain flexible throughout the process of choosing a research topic. As you delve deeper into the literature and research process, you may discover new avenues of interest or encounter unexpected challenges. It is essential to remain open to refining or adjusting your research topic based on new insights, emerging data, or feedback from your research advisors. Flexibility allows you to adapt and ensure that your research remains relevant and impactful.

Choosing a pharmacology research paper topic is an exciting and important step in your academic journey. By following expert advice, identifying your interests, staying updated with current research, seeking guidance, considering practicality and resources, addressing current challenges or gaps, collaborating with peers, adhering to ethical considerations, evaluating feasibility and novelty, consulting literature reviews, and remaining flexible, you can select a research topic that is engaging, relevant, and has the potential to contribute to the field of pharmacology. Remember, this is your opportunity to explore, innovate, and make a lasting impact in the dynamic field of pharmacology research.

How to Write a Pharmacology Research Paper

Writing a pharmacology research paper requires careful planning, organization, and attention to detail. It is an opportunity for you to showcase your understanding of the subject matter, critical thinking skills, and ability to communicate scientific information effectively. In this section, we will provide you with expert guidance on how to write a pharmacology research paper that is well-structured, informative, and compelling.

• Choose a Well-Defined Research Question : Start by formulating a clear and well-defined research question. Your research question should be focused, specific, and address a gap in the existing knowledge. Consider the significance of your research question in the context of pharmacology and how it contributes to the overall understanding of the field. A well-defined research question sets the foundation for your entire research paper.
• Conduct a Thorough Literature Review : Before diving into your research, conduct a thorough literature review on the chosen topic. Familiarize yourself with the existing research, theories, and findings related to your research question. This will provide you with a solid understanding of the current state of knowledge and help you identify gaps or areas for further investigation. Additionally, the literature review will inform your research methodology and discussion of results.
• Develop a Clear Structure : A well-structured research paper is essential for effectively conveying your ideas and findings. Begin with an engaging introduction that provides background information, context, and clearly states your research question. Follow with a comprehensive literature review that supports your research question and highlights the gaps in knowledge. Next, present your research methodology, including details on sample selection, data collection, and analysis methods. In the results section, present your findings in a clear and organized manner using tables, graphs, or figures as necessary. Finally, discuss your results, interpret their significance, and relate them back to your research question in the discussion section. Conclude with a concise summary of your findings and their implications.
• Use Reliable and Credible Sources : Ensure that the sources you use for your research paper are reliable, credible, and peer-reviewed. Consult reputable scientific journals, textbooks, and conference proceedings. Avoid relying solely on internet sources or non-scholarly publications. Citations are critical to acknowledge the work of other researchers and to support your claims and arguments. Use a consistent citation style, such as APA, MLA, or Chicago, and follow the guidelines carefully.
• Analyze and Interpret Your Data : If your research involves collecting and analyzing data, ensure that your data analysis is thorough and accurate. Use appropriate statistical methods to analyze your data and present the results in a clear and meaningful way. Interpret the findings in the context of your research question and discuss any limitations or potential sources of bias. Remember to relate your findings back to the existing literature and explain how they contribute to the broader understanding of pharmacology.
• Write Clearly and Concisely : Effective scientific writing is clear, concise, and free of unnecessary jargon. Use language that is precise and straightforward, avoiding ambiguous or vague statements. Clearly articulate your ideas and ensure that your arguments are logical and well-supported by evidence. Use appropriate scientific terminology, but also consider your target audience and strive to communicate your findings in a way that is accessible to readers who may not have expertise in pharmacology.
• Pay Attention to Formatting and Style : Follow the formatting and style guidelines specified by your instructor or the target journal. Pay attention to details such as font size, line spacing, margins, and headings. Use subheadings to organize your content and make it easier for readers to navigate. Adhere to the specific citation style required for your paper and ensure that your references are complete and accurate.
• Revise and Edit : Revision and editing are essential steps in the writing process. Take the time to review your research paper for clarity, coherence, and accuracy. Check for grammatical errors, spelling mistakes, and punctuation errors. Ensure that your ideas flow logically and that your paper is well-structured. Consider seeking feedback from peers, instructors, or mentors to gain different perspectives and improve the overall quality of your paper.
• Proofread : Before submitting your research paper, thoroughly proofread it to ensure that it is error-free. Check for any typos, inconsistencies, or formatting issues. Read your paper aloud to catch any awkward phrasing or unclear sentences. It can also be helpful to have someone else read your paper to identify any errors or areas that need improvement.
• Ethical Considerations : Ensure that your research paper adheres to ethical considerations. If your research involved human subjects, ensure that you have obtained the necessary approvals and informed consent. Respect patient confidentiality and anonymity when presenting your research findings. Adhere to the ethical guidelines set by your institution or the relevant regulatory bodies.

Writing a pharmacology research paper requires careful planning, thorough research, effective communication, and attention to detail. By following the expert advice provided in this section, you can develop a well-structured and informative research paper that contributes to the field of pharmacology. Remember to choose a well-defined research question, conduct a thorough literature review, use reliable sources, analyze and interpret your data, write clearly and concisely, pay attention to formatting and style, revise and edit your paper, proofread for errors, and ensure ethical considerations are met. With diligence and commitment, your pharmacology research paper has the potential to make a meaningful impact in the field of pharmacology.

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Clinical Pharmacology: Current Topics and Case Studies

• © 2016
• Latest edition
• Markus Müller 0

Universitätsklinik für Klinische, Medizinische Universität Wien, Wien, Austria

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Updated and revised 2nd edition

Summarizes the latest topics, tools and clinical trials in clinical pharmacology

Added value for employees in drug research and development

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Table of contents (23 chapters)

Front matter, introduction, the discipline of clinical pharmacology.

Markus Müller

Current Issues in Drug Development

Current issues in drug regulation.

• Christa Wirthumer-Hoche, Brigitte Bloechl-Daum

Current Topics in Drug Reimbursement

• Anna Bucsics, Robert Sauermann, Valerie Nell-Duxneuner

Clinical Trials

Ethics in clinical research.

• Ernst Singer, Christiane Druml

Good Clinical Practice (GCP) and Scientific Misconduct

• Brigitte Bloechl-Daum

Phase I Studies and First-In-Human Trials

• Ulla Derhaschnig, Bernd Jilma

Clinical Trials: Interventional Studies

• Michael Wolzt, Stefan Aschauer

Observational Studies

• Harald Herkner, Christoph Male

Tools in Clinical Pharmacology

Tools in clinical pharmacology: imaging techniques.

• Martin Bauer, Oliver Langer

Pharmacokinetics II: 14C-Labelled Microdosing in Assessing Drug Pharmacokinetics at Phase 0

• Graham Lappin

Current Concepts of Pharmacogenetics, Pharmacogenomics, and the “Druggable” Genome

• Wolfgang M. Schmidt, Robert M. Mader

Pharmacokinetics I: PK-PD Approach, the Case of Antibiotic Drug Development

• Sherwin K. B. Sy, Hartmut Derendorf

Epidemiology and Biostatistics

• Gerhard Garhöfer, Leopold Schmetterer

Placebo Effects and Placebo Control in Clinical Trials

• Johannes Pleiner-Duxneuner

Topics in Clinical Pharmacology

• drug development
• clinical trial
• gene therapy
• pharmacodynamics
• drug research
• pharmacotherapy

About this book

“The aim is to describe the role of the discipline of clinical pharmacology in drug discovery. … The intended audience is faculty, researchers, and advanced students from academia and the pharmaceutical industry who are learning about or involved in the process of drug discovery. … This book provides a multitude of very useful insights about the successes and failures in drug development for scientists who are, or will be, involved in the process of drug discovery.” (Thomas L. Pazdernik, Doody's Book Reviews, May, 2016)

Editors and Affiliations

About the editor, bibliographic information.

Book Title : Clinical Pharmacology: Current Topics and Case Studies

Editors : Markus Müller

DOI : https://doi.org/10.1007/978-3-319-27347-1

Publisher : Springer Cham

eBook Packages : Biomedical and Life Sciences , Biomedical and Life Sciences (R0)

Copyright Information : Springer International Publishing Switzerland 2016

Hardcover ISBN : 978-3-319-27345-7 Published: 25 March 2016

Softcover ISBN : 978-3-319-80118-6 Published: 25 April 2018

eBook ISBN : 978-3-319-27347-1 Published: 15 March 2016

Edition Number : 2

Number of Pages : VI, 405

Number of Illustrations : 14 b/w illustrations, 16 illustrations in colour

Topics : Pharmacology/Toxicology , Pharmacy , Pharmacotherapy

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• Shifting our perspective on orphan G protein-coupled receptors. Smith NJ, Murray F. Shifting our perspective on orphan G protein-coupled receptors. (2024)   Nat Struct Mol Biol , [Epub ahead of print]. [PMID: 38565695 ]
• AI is a viable alternative to high throughput screening: a 318-target study. Atomwise AIMS Program. AI is a viable alternative to high throughput screening: a 318-target study. (2024)   Sci Rep , 14 (1): 7526. [PMID: 38565852 ]
• MFSD7c functions as a transporter of choline at the blood-brain barrier. Nguyen XTA, Le TNU, Nguyen TQ, Thi Thuy Ha H, Artati A, Leong NCP, Nguyen DT, Lim PY, Susanto AV, Huang Q et al. . MFSD7c functions as a transporter of choline at the blood-brain barrier. (2024)   Cell Res , 34 (3): 245-257. [PMID: 38302740 ]
• Orphan lysosomal solute carrier MFSD1 facilitates highly selective dipeptide transport. Boytsov D, Madej GM, Horn G, Blaha N, Köcher T, Sitte HH, Siekhaus D, Ziegler C, Sandtner W, Roblek M. Orphan lysosomal solute carrier MFSD1 facilitates highly selective dipeptide transport. (2024)   Proc Natl Acad Sci U S A , 121 (13): e2319686121. [PMID: 38507452 ]
• Activation of GPR81 by lactate drives tumour-induced cachexia. Liu X, Li S, Cui Q, Guo B, Ding W, Liu J, Quan L, Li X, Xie P, Jin L et al. . Activation of GPR81 by lactate drives tumour-induced cachexia. (2024)   Nat Metab , [Epub ahead of print]. [PMID: 38499763 ]
• The kainate receptor GluK2 mediates cold sensing in mice. Cai W, Zhang W, Zheng Q, Hor CC, Pan T, Fatima M, Dong X, Duan B, Xu XZS. The kainate receptor GluK2 mediates cold sensing in mice. (2024)   Nat Neurosci , [Epub ahead of print]. [PMID: 38467901 ]
• An evolutionarily conserved olfactory receptor is required for sex differences in blood pressure. Xu J, Choi R, Gupta K, Warren HR, Santhanam L, Pluznick JL. An evolutionarily conserved olfactory receptor is required for sex differences in blood pressure. (2024)   Sci Adv , 10 (12): eadk1487. [PMID: 38507492 ]
• Understanding the provenance and quality of methods is essential for responsible reuse of FAIR data. Weissgerber TL, Gazda MA, Nilsonne G, Ter Riet G, Cobey KD, Prieß-Buchheit J, Noro J, Schulz R, Tijdink JK, Bobrov E et al. . Understanding the provenance and quality of methods is essential for responsible reuse of FAIR data. (2024)   Nat Med , [Epub ahead of print]. [PMID: 38514869 ]
• Promoting gender equity in the scientific and health workforce is essential to improve women's health. Vieira Machado C, Araripe Ferreira C, de Souza Mendes Gomes MA. Promoting gender equity in the scientific and health workforce is essential to improve women's health. (2024)   Nat Med , [Epub ahead of print]. [PMID: 38519768 ]

January 2024

• Persistent complement dysregulation with signs of thromboinflammation in active Long Covid. Cervia-Hasler C, Brüningk SC, Hoch T, Fan B, Muzio G, Thompson RC, Ceglarek L, Meledin R, Westermann P, Emmenegger M et al. . Persistent complement dysregulation with signs of thromboinflammation in active Long Covid. (2024)   Science , 383 (6680): eadg7942. [PMID: 38236961 ]
• EPAC1 enhances brown fat growth and beige adipogenesis. Reverte-Salisa L, Siddig S, Hildebrand S, Yao X, Zurkovic J, Jaeckstein MY, Heeren J, Lezoualc'h F, Krahmer N, Pfeifer A. EPAC1 enhances brown fat growth and beige adipogenesis. (2024)   Nat Cell Biol , 26 (1): 113-123. [PMID: 38195707 ]
• Chemoproteomic development of SLC15A4 inhibitors with anti-inflammatory activity. Chiu TY, Lazar DC, Wang WW, Wozniak JM, Jadhav AM, Li W, Gazaniga N, Theofilopoulos AN, Teijaro JR, Parker CG. Chemoproteomic development of SLC15A4 inhibitors with anti-inflammatory activity. (2024)   Nat Chem Biol , [Epub ahead of print]. [PMID: 38191941 ]
• Insights for precision oncology from the integration of genomic and clinical data of 13,880 tumors from the 100,000 Genomes Cancer Programme. Sosinsky A, Ambrose J, Cross W, Turnbull C, Henderson S, Jones L, Hamblin A, Arumugam P, Chan G, Chubb D et al. . Insights for precision oncology from the integration of genomic and clinical data of 13,880 tumors from the 100,000 Genomes Cancer Programme. (2024)   Nat Med , 30 (1): 279-289. [PMID: 38200255 ]
• Structural basis of prostaglandin efflux by MRP4. Pourmal S, Green E, Bajaj R, Chemmama IE, Knudsen GM, Gupta M, Sali A, Cheng Y, Craik CS, Kroetz DL et al. . Structural basis of prostaglandin efflux by MRP4. (2024)   Nat Struct Mol Biol , [Epub ahead of print]. [PMID: 38216659 ]
• Biased agonists of GPR84 and insights into biological control. Luscombe VB, Wang P, Russell AJ, Greaves DR. Biased agonists of GPR84 and insights into biological control. (2023)   Br J Pharmacol , [Epub ahead of print]. [PMID: 38148720 ]

November 2023

• Open science discovery of potent noncovalent SARS-CoV-2 main protease inhibitors. Boby ML, Fearon D, Ferla M, Filep M, Koekemoer L, Robinson MC, COVID Moonshot Consortium‡, Chodera JD, Lee AA, London N et al. . Open science discovery of potent noncovalent SARS-CoV-2 main protease inhibitors. (2023)   Science , 382 (6671): eabo7201. [PMID: 37943932 ]

October 2023

• The IUPHAR/BPS Guide to PHARMACOLOGY in 2024. Harding SD, Armstrong JF, Faccenda E, Southan C, Alexander SPH, Davenport AP, Spedding M, Davies JA. The IUPHAR/BPS Guide to PHARMACOLOGY in 2024. (2024)   Nucleic Acids Res , 52 (D1): D1438-D1449. [PMID: 37897341 ]
• ADCdb: the database of antibody-drug conjugates. Shen L, Sun X, Chen Z, Guo Y, Shen Z, Song Y, Xin W, Ding H, Ma X, Xu W et al. . ADCdb: the database of antibody-drug conjugates. (2024)   Nucleic Acids Res , 52 (D1): D1097-D1109. [PMID: 37831118 ]
• TTD: Therapeutic Target Database describing target druggability information. Zhou Y, Zhang Y, Zhao D, Yu X, Shen X, Zhou Y, Wang S, Qiu Y, Chen Y, Zhu F. TTD: Therapeutic Target Database describing target druggability information. (2024)   Nucleic Acids Res , 52 (D1): D1465-D1477. [PMID: 37713619 ]
• Functional screening and rational design of compounds targeting GPR132 to treat diabetes. Wang JL, Dou XD, Cheng J, Gao MX, Xu GF, Ding W, Ding JH, Li Y, Wang SH, Ji ZW et al. . Functional screening and rational design of compounds targeting GPR132 to treat diabetes. (2023)   Nat Metab , 5 (10): 1726-1746. [PMID: 37770763 ]
• Genome-wide association analysis reveals insights into the molecular etiology underlying dilated cardiomyopathy. Zheng SL, Henry A, Cannie D, Lee M, Miller D, McGurk KA, Bond I, Xu X, Issa H, Francis C et al. . Genome-wide association analysis reveals insights into the molecular etiology underlying dilated cardiomyopathy. (2023)   medRxiv , Preprint. DOI: https://www.medrxiv.org/content/10.1101/2023.09.28.23295408v1
• An inverse agonist of orphan receptor GPR61 acts by a G protein-competitive allosteric mechanism. Lees JA, Dias JM, Rajamohan F, Fortin JP, O'Connor R, Kong JX, Hughes EAG, Fisher EL, Tuttle JB, Lovett G et al. . An inverse agonist of orphan receptor GPR61 acts by a G protein-competitive allosteric mechanism. (2023)   Nat Commun , 14 (1): 5938. [PMID: 37741852 ]
• Cryo-EM structures of human GPR34 enable the identification of selective antagonists. Xia A, Yong X, Zhang C, Lin G, Jia G, Zhao C, Wang X, Hao Y, Wang Y, Zhou P et al. . Cryo-EM structures of human GPR34 enable the identification of selective antagonists. (2023)   Proc Natl Acad Sci U S A , 120 (39): e2308435120. [PMID: 37733739 ]

September 2023

• The Batten disease gene product CLN5 is the lysosomal bis(monoacylglycero)phosphate synthase. Medoh UN, Hims A, Chen JY, Ghoochani A, Nyame K, Dong W, Abu-Remaileh M. The Batten disease gene product CLN5 is the lysosomal bis(monoacylglycero)phosphate synthase. (2023)   Science , 381 (6663): 1182-1189. [PMID: 37708259 ]
• Neuromedin U programs eosinophils to promote mucosal immunity of the small intestine. Li Y, Liu S, Zhou K, Wang Y, Chen Y, Hu W, Li S, Li H, Wang Y, Wang Q et al. . Neuromedin U programs eosinophils to promote mucosal immunity of the small intestine. (2023)   Science , 381 (6663): 1189-1196. [PMID: 37708282 ]
• Exploring DrugCentral: from molecular structures to clinical effects. Halip L, Avram S, Curpan R, Borota A, Bora A, Bologa C, Oprea TI. Exploring DrugCentral: from molecular structures to clinical effects. (2023)   J Comput Aided Mol Des , 37 (12): 681-694. [PMID: 37707619 ]
• Role of sphingolipids in the host-pathogen interaction. Matos GS, Fernandes CM, Del Poeta M. Role of sphingolipids in the host-pathogen interaction. (2023)   Biochim Biophys Acta Mol Cell Biol Lipids , 1868 (11): 159384. [PMID: 37673393 ]
• Dynamic lipidome alterations associated with human health, disease and ageing. Hornburg D, Wu S, Moqri M, Zhou X, Contrepois K, Bararpour N, Traber GM, Su B, Metwally AA, Avina M et al. . Dynamic lipidome alterations associated with human health, disease and ageing. (2023)   Nat Metab , 5 (9): 1578-1594. [PMID: 37697054 ]
• Global analysis of aging-related protein structural changes uncovers enzyme-polymerization-based control of longevity. Paukštytė J, López Cabezas RM, Feng Y, Tong K, Schnyder D, Elomaa E, Gregorova P, Doudin M, Särkkä M, Sarameri J et al. . Global analysis of aging-related protein structural changes uncovers enzyme-polymerization-based control of longevity. (2023)   Mol Cell , 83 (18): 3360-3376.e11. [PMID: 37699397 ]
• Mitochondrial degradation: Mitophagy and beyond. Uoselis L, Nguyen TN, Lazarou M. Mitochondrial degradation: Mitophagy and beyond. (2023)   Mol Cell , 83 (19): 3404-3420. [PMID: 37708893 ]
• How many kinases are druggable? A review of our current understanding. Anderson B, Rosston P, Ong HW, Hossain MA, Davis-Gilbert ZW, Drewry DH. How many kinases are druggable? A review of our current understanding. (2023)   Biochem J , 480 (16): 1331-1363. [PMID: 37642371 ]
• AI-powered therapeutic target discovery. Pun FW, Ozerov IV, Zhavoronkov A. AI-powered therapeutic target discovery. (2023)   Trends Pharmacol Sci , 44 (9): 561-572. [PMID: 37479540 ]

August 2023

• What is a cell type?. Fleck JS, Camp JG, Treutlein B. What is a cell type?. (2023)   Science , 381 (6659): 733-734. [PMID: 37590360 ]
• Create a culture of experiments in environmental programs. Ferraro PJ, Cherry TL, Shogren JF, Vossler CA, Cason TN, Flint HB, Hochard JP, Johansson-Stenman O, Martinsson P, Murphy JJ et al. . Create a culture of experiments in environmental programs. (2023)   Science , 381 (6659): 735-737. [PMID: 37590363 ]
• International Union of Basic and Clinical Pharmacology CXIII: Nuclear Receptor Superfamily-Update 2023. Burris TP, de Vera IMS, Cote I, Flaveny CA, Wanninayake US, Chatterjee A, Walker JK, Steinauer N, Zhang J, Coons LA et al. . International Union of Basic and Clinical Pharmacology CXIII: Nuclear Receptor Superfamily-Update 2023. (2023)   Pharmacol Rev , 75 (6): 1233-1318. [PMID: 37586884 ]
• A method for structure determination of GPCRs in various states. Guo Q, He B, Zhong Y, Jiao H, Ren Y, Wang Q, Ge Q, Gao Y, Liu X, Du Y et al. . A method for structure determination of GPCRs in various states. (2024)   Nat Chem Biol , 20 (1): 74-82. [PMID: 37580554 ]
• A preclinical secondary pharmacology resource illuminates target-adverse drug reaction associations of marketed drugs. Sutherland JJ, Yonchev D, Fekete A, Urban L. A preclinical secondary pharmacology resource illuminates target-adverse drug reaction associations of marketed drugs. (2023)   Nat Commun , 14 (1): 4323. [PMID: 37468498 ]
• Metal-ion transporter SLC39A8 is required for brain manganese uptake and accumulation. Liu Q, Jenkitkasemwong S, Prami TA, McCabe SM, Zhao N, Hojyo S, Fukada T, Knutson MD. Metal-ion transporter SLC39A8 is required for brain manganese uptake and accumulation. (2023)   J Biol Chem , 299 (8): 105078. [PMID: 37482277 ]
• Cross-talk between zinc and calcium regulates ion transport: A role for the zinc receptor, ZnR/GPR39. Hershfinkel M. Cross-talk between zinc and calcium regulates ion transport: A role for the zinc receptor, ZnR/GPR39. (2023)   J Physiol , [Epub ahead of print]. [PMID: 37462604 ]
• Identification of ligand-receptor pairs that drive human astrocyte development. Voss AJ, Lanjewar SN, Sampson MM, King A, Hill EJ, Sing A, Sojka C, Bhatia TN, Spangle JM, Sloan SA. Identification of ligand-receptor pairs that drive human astrocyte development. (2023)   Nat Neurosci , 26 (8): 1339-1351. [PMID: 37460808 ]
• Jeffrey Clifton Watkins FRS - The father of the glutamate receptor. Collingridge GL, Evans RH, Jane DE, Lodge D. Jeffrey Clifton Watkins FRS - The father of the glutamate receptor. (2023)   Neuropharmacology ,: 109650 [Epub ahead of print]. [PMID: 37474350 ]
• The manifold costs of being a non-native English speaker in science. Amano T, Ramírez-Castañeda V, Berdejo-Espinola V, Borokini I, Chowdhury S, Golivets M, González-Trujillo JD, Montaño-Centellas F, Paudel K, White RL et al. . The manifold costs of being a non-native English speaker in science. (2023)   PLoS Biol , 21 (7): e3002184. [PMID: 37463136 ]
• Spartin is a receptor for the autophagy of lipid droplets. Spartin is a receptor for the autophagy of lipid droplets. (2023)   Nat Cell Biol , 25 (8): 1085-1086. [PMID: 37474818 ]
• Profiling of basal and ligand-dependent GPCR activities by means of a polyvalent cell-based high-throughput platform. Zeghal M, Laroche G, Freitas JD, Wang R, Giguère PM. Profiling of basal and ligand-dependent GPCR activities by means of a polyvalent cell-based high-throughput platform. (2023)   Nat Commun , 14 (1): 3684. [PMID: 37407564 ]
• Mammalian type opsin 5 preferentially activates G14 in Gq-type G proteins triggering intracellular calcium response. Sato K, Yamashita T, Ohuchi H. Mammalian type opsin 5 preferentially activates G14 in Gq-type G proteins triggering intracellular calcium response. (2023)   J Biol Chem , 299 (8): 105020. [PMID: 37423300 ]
• Cryo-EM structure of GABA transporter 1 reveals substrate recognition and transport mechanism. Nayak SR, Joseph D, Höfner G, Dakua A, Athreya A, Wanner KT, Kanner BI, Penmatsa A. Cryo-EM structure of GABA transporter 1 reveals substrate recognition and transport mechanism. (2023)   Nat Struct Mol Biol , 30 (7): 1023-1032. [PMID: 37400654 ]
• Molecular basis for substrate recognition and transport of human GABA transporter GAT1. Zhu A, Huang J, Kong F, Tan J, Lei J, Yuan Y, Yan C. Molecular basis for substrate recognition and transport of human GABA transporter GAT1. (2023)   Nat Struct Mol Biol , 30 (7): 1012-1022. [PMID: 37400655 ]
• Advances in malaria pharmacology and the online guide to MALARIA PHARMACOLOGY: IUPHAR review 38. Armstrong JF, Campo B, Alexander SPH, Arendse LB, Cheng X, Davenport AP, Faccenda E, Fidock DA, Godinez-Macias KP, Harding SD et al. . Advances in malaria pharmacology and the online guide to MALARIA PHARMACOLOGY: IUPHAR review 38. (2023)   Br J Pharmacol , 180 (15): 1899-1929. [PMID: 37197802 ]
• The VGNC: expanding standardized vertebrate gene nomenclature. Jones TEM, Yates B, Braschi B, Gray K, Tweedie S, Seal RL, Bruford EA. The VGNC: expanding standardized vertebrate gene nomenclature. (2023)   Genome Biol , 24 (1): 115. [PMID: 37173739 ]
• A small-molecule PI3Kα activator for cardioprotection and neuroregeneration. Gong GQ, Bilanges B, Allsop B, Masson GR, Roberton V, Askwith T, Oxenford S, Madsen RR, Conduit SE, Bellini D et al. . A small-molecule PI3Kα activator for cardioprotection and neuroregeneration. (2023)   Nature , 618 (7963): 159-168. [PMID: 37225977 ]
• Bilirubin gates the TRPM2 channel as a direct agonist to exacerbate ischemic brain damage. Liu HW, Gong LN, Lai K, Yu XF, Liu ZQ, Li MX, Yin XL, Liang M, Shi HS, Jiang LH et al. . Bilirubin gates the TRPM2 channel as a direct agonist to exacerbate ischemic brain damage. (2023)   Neuron , 111 (10): 1609-1625.e6. [PMID: 36921602 ]
• FDA approves first-in-class NK3 receptor antagonist for hot flushes. Mullard A. FDA approves first-in-class NK3 receptor antagonist for hot flushes. (2023)   Nat Rev Drug Discov , 22 (7): 526. [PMID: 37208488 ]
• Identification and classification of papain-like cysteine proteinases. Ozhelvaci F, Steczkiewicz K. Identification and classification of papain-like cysteine proteinases. (2023)   J Biol Chem , 299 (6): 104801. [PMID: 37164157 ]

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• Advancing Pharmacoequity in Atrial Fibrillation—The Case for Direct Oral Anticoagulants JAMA Network Open Opinion May 6, 2024 Health Disparities Anticoagulation Health Policy Pharmacy and Clinical Pharmacology Health Inequities Full Text | pdf link PDF open access

This cross-sectional study analyzes changes and disparities in comprehensive medication review (CMR) completion rates before and after implementation of a 2016 Medicare Star Rating quality measure.

• Therapeutic Psilocybin's Adverse Effects Mostly Resolved Within 2 Days JAMA News May 3, 2024 Adverse Drug Events Full Text | pdf link PDF free
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This study evaluates the characteristics of generic active pharmaceutical ingredients (APIs) used to manufacture drugs with shortages in the US and facilities producing APIs worldwide.

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• Interpreting the Findings of the POHIM-CCRT Trial JAMA Oncology Opinion April 25, 2024 Reproductive Health Oncology Radiation Oncology Gynecologic Cancer Adverse Drug Events Full Text | pdf link PDF

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Pharmacology articles within Nature

Article | 10 April 2024

Bitter taste receptor activation by cholesterol and an intracellular tastant

Cryo-electron microscopy structures of the type 2 taste receptor TAS2R14 in complex with Ggust and Gi1 identify cholesterol as an orthosteric agonist and the bitter tastant cmpd28.1 as a positive allosteric modulator and agonist.

• Yoojoong Kim
• , Ryan H. Gumpper
•  &  Bryan L. Roth

Article | 08 April 2024

Tumor-selective activity of RAS-GTP inhibition in pancreatic cancer

• Urszula N. Wasko
• , Jingjing Jiang
•  &  Kenneth P. Olive

Article | 07 November 2023

Recognition of methamphetamine and other amines by trace amine receptor TAAR1

We report on the structures of the TAAR1–G-protein complex when bound to methamphetamine and other amines.

• , You Zheng
•  &  Fei Xu

Article | 31 July 2023

Conserved class B GPCR activation by a biased intracellular agonist

A study reports an orally available small-molecule agonist that binds between a G protein and its receptor, and characterizes this new binding mode.

• Li-Hua Zhao
•  &  H. Eric Xu

Article 07 June 2023 | Open Access

Class B1 GPCR activation by an intracellular agonist

A new intracellular agonist-binding pocket is identified that is common to many G protein-coupled receptors, which will have implications for the development of biased compounds that target this large group of receptors.

• Kazuhiro Kobayashi
• , Kouki Kawakami
•  &  Osamu Nureki

Article 03 May 2023 | Open Access

Ligand and G-protein selectivity in the κ-opioid receptor

Active-state structures of the κ-opioid receptor in complexes with the G-protein heterotrimers G i1 , G oA , G z and G g provide insights into the actions of hallucinogenic opioids and G-protein-coupling specificity at the κ-opioid receptor.

• Jianming Han
• , Jingying Zhang
•  &  Tao Che

Article | 15 March 2023

Structural basis of odorant recognition by a human odorant receptor

Through the use of cryo-electron microscopy and molecular dynamics stimulations, mechanistic insight into the binding of an odorant to the human odorant receptor OR51E2 is provided.

• Christian B. Billesbølle
• , Claire A. de March
•  &  Aashish Manglik

Article | 08 March 2023

Molecular sensing of mechano- and ligand-dependent adhesion GPCR dissociation

A technique to detect the release of N-terminal fragments of Drosophila adhesion G-protein-coupled receptors (aGPCRs) provides insight into the dissociation of aGPCRs, and shows that receptor autoproteolysis enables non-cell-autonomous activity of aGPCRs in the brain.

• Nicole Scholz
• , Anne-Kristin Dahse
•  &  Tobias Langenhan

Article | 30 November 2022

Structure-based design of bitopic ligands for the µ-opioid receptor

Bitopic functionalized ligands based on fentanyl can target the sodium ion-binding site of the mu-opioid receptor and selectively modulate downstream signalling pathways, potentially leading to safer analgesics.

• Abdelfattah Faouzi
• , Haoqing Wang
•  &  Susruta Majumdar

Article 14 September 2022 | Open Access

Brain-restricted mTOR inhibition with binary pharmacology

The combination of the brain-permeable mTOR inhibitor RapaLink-1 and the brain-impermeable FKBP12 ligand RapaBlock enable brain-specific inhibition of mTOR.

• Ziyang Zhang
• , Qiwen Fan
•  &  Kevan M. Shokat

Article | 08 August 2022

Autoantibody mimicry of hormone action at the thyrotropin receptor

Cryo-electron microscopy structures of the thyrotropin receptor reveal the basis for the activation of the receptor by autoantibodies in patients with Graves’ disease.

• Bryan Faust
• , Christian B. Billesbølle

Article | 08 June 2022

Structural basis of GABA reuptake inhibition

Structural determination of GAT1 using cryo-electron microscopy provides insights into the biology and pharmacology of this GABA transporter.

• Zenia Motiwala
• , Nanda Gowtham Aduri
•  &  Cornelius Gati

Article | 08 December 2021

Structures of the σ 2 receptor enable docking for bioactive ligand discovery

Crystal structures of the σ 2 receptor are determined and used to perform a docking screen of nearly 500 million molecules, identifying σ 2 -selective ligands and providing insight into the role of σ 2 in neuropathic pain.

• , Jiankun Lyu
•  &  Andrew C. Kruse

Structural basis of inhibition of the human SGLT2–MAP17 glucose transporter

Using cryogenic electron microscopy, the structure of the human SGLT2–MAP17 complex captured in the empagliflozin-bound state reveals the inhibitory mechanism of these anti-diabetic drugs.

•  &  Lei Chen

Article | 17 November 2021

Structure, function and pharmacology of human itch receptor complexes

Cryo-electron microscopy structures of the MRGPRX2–G i1 trimer in complex with polycationic compound 48/80 or inflammatory peptides provide insights into the sensing of cationic allergens by MRGPRX2, potentially facilitating the design of therapies to prevent unwanted pseudoallergic reactions.

•  &  Jin-Peng Sun

Article | 08 September 2021

Positive allosteric mechanisms of adenosine A 1 receptor-mediated analgesia

MIPS521, a positive allosteric modulator of the adenosine A 1 receptor, has analgesic properties in a rat model of neuropathic pain through a mechanism by which MIPS521 stabilizes the complex between adenosine, receptor and G protein.

• Christopher J. Draper-Joyce
• , Rebecca Bhola
•  &  Arthur Christopoulos

Article | 24 March 2021

Structural insights into the lipid and ligand regulation of serotonin receptors

Cryo-electron microscopy structures of three different serotonin receptors in complex with serotonin and other agonists provide insights into the role of lipids in regulating these receptors and the structural basis of ligand recognition.

• , Sijie Huang

Article | 09 December 2020

A non-hallucinogenic psychedelic analogue with therapeutic potential

Psychedelic alkaloids served as lead structures for the development of tabernanthalog, a non-hallucinogenic and non-toxic analogue that reduces alcohol- and heroin-seeking behaviour and produces antidepressant-like effects in rodents.

• Lindsay P. Cameron
• , Robert J. Tombari
•  &  David E. Olson

Article | 22 July 2020

Structural basis of GPBAR activation and bile acid recognition

Using cryo-electron microscopy, the authors report the structures of G-protein-coupled bile acid receptor–G s complexes and reveal the structural basis of bile acid recognition.

• , Chunyou Mao
•  &  Yan Zhang

Article | 10 February 2020

Virtual discovery of melatonin receptor ligands to modulate circadian rhythms

A computational screen of an ultra-large virtual library against the structure of the melatonin receptor found nanomolar ligands, and ultimately two selective MT 1 inverse agonists that induced phase advancement of the mouse circadian clock when given at subjective dusk.

• Reed M. Stein
• , Hye Jin Kang
•  &  Margarita L. Dubocovich

Article | 16 January 2020

Structure of the neurotensin receptor 1 in complex with β-arrestin 1

A cryo-electron microscopy structure of the neurotensin receptor 1 in complex with β-arrestin 1 is reported.

• Weijiao Huang
• , Matthieu Masureel
•  &  Brian K. Kobilka

Article | 08 January 2020

Activation of the GLP-1 receptor by a non-peptidic agonist

The structure of GLP-1R and its G protein in complex with the small molecule TT-OAD2 sheds light on how the TT-OAD2 agonist can activate the receptor and provides insights into the development of therapeutic agents for metabolic disorders.

• Peishen Zhao
• , Yi-Lynn Liang
•  &  Denise Wootten

Article | 02 January 2019

GABA A receptor signalling mechanisms revealed by structural pharmacology

Cryo-electron microscopy structures are reported in which the full-length human α1β3γ2L GABA A receptor in lipid nanodiscs is bound to the channel-blocker picrotoxin, the competitive antagonist bicuculline, the agonist GABA, and the benzodiazepines alprazolam and diazepam.

• Simonas Masiulis
• , Rooma Desai
•  &  A. Radu Aricescu

Article | 12 September 2018

Optimized arylomycins are a new class of Gram-negative antibiotics

Chemical optimization of arylomycins results in an inhibitor of bacterial type I signal peptidase that shows activity both against multidrug-resistant clinical isolates of Gram-negative bacteria in vitro and in several in vivo infection models.

• Peter A. Smith
• , Michael F. T. Koehler
•  &  Christopher E. Heise

Review Article | 04 July 2018

Structural insights into G-protein-coupled receptor allostery

High-resolution structural studies of GPCRs have led to insights into the role of allostery in GPCR-mediated signal transduction.

• David M. Thal
• , Alisa Glukhova

Article | 20 June 2018

Structure of the adenosine-bound human adenosine A 1 receptor–G i complex

The cryo-electron microscopy structure of the human adenosine A 1 receptor in complex with adenosine and heterotrimeric G i2 protein provides molecular insights into receptor and G-protein selectivity.

• , Maryam Khoshouei

Article | 13 June 2018

Structure of the µ-opioid receptor–G i protein complex

A cryo-electron structure of the µ-opioid receptor in complex with the peptide agonist DAMGO and the inhibitory G protein G i reveals structural determinants of its G protein-binding specificity.

• Antoine Koehl
• , Hongli Hu

Letter | 24 January 2018

Structure of the D2 dopamine receptor bound to the atypical antipsychotic drug risperidone

An X-ray structure of the D2 dopamine receptor bound to the atypical antipsychotic drug risperidone reveals an extended binding pocket and indicates structural features that could be used to design drugs that specifically target the D2 receptor.

Letter | 16 August 2017

Vaccine-driven pharmacodynamic dissection and mitigation of fenethylline psychoactivity

A vaccine-driven approach shows that the prominent stimulant features of the psychoactive profile of fenethylline can be attributed to amphetamine, with synergistic support from theophylline, and no direct contributions from the parent drug molecule.

• Cody J. Wenthur
•  &  Kim D. Janda

Article | 31 May 2017

Crystal structure of the GLP-1 receptor bound to a peptide agonist

The solved crystal structure of the GLP-1 receptor bound to a truncated agonist enables the design of synthetic agonists that exhibit potent activity in vivo .

• Ali Jazayeri
• , Mathieu Rappas
•  &  Fiona H. Marshall

Letter | 26 April 2017

Structural insight into allosteric modulation of protease-activated receptor 2

Crystal structures of protease-activated receptor 2 (PAR2) in complex with two different antagonist ligands and with a blocking antibody reveal binding sites that are distinct from those found on PAR1, offering new leads for structure-based drug design.

• Robert K. Y. Cheng
• , Cédric Fiez-Vandal
•  &  Niek Dekker

Article | 24 April 2017

Phase-plate cryo-EM structure of a class B GPCR–G-protein complex

Volta phase-plate cryo-electron microscopy reveals the structure of the full-length calcitonin receptor in complex with its peptide ligand and Gα s βγ.

• Yi-Lynn Liang
•  &  Patrick M. Sexton

Letter | 22 March 2017

The allosteric inhibitor ABL001 enables dual targeting of BCR–ABL1

The selective allosteric ABL1 inhibitor ABL001 (asciminib) represents a new inhibitory mechanism for BCR–ABL1-driven malignancies, and its efficacy and evolving mechanisms of resistance do not overlap with those of other BCR–ABL1 kinase inhibitors.

• Andrew A. Wylie
• , Joseph Schoepfer
•  &  William R. Sellers

Letter | 07 December 2016

Structure of CC chemokine receptor 2 with orthosteric and allosteric antagonists

The crystal structure of CCR2 chemokine receptor in a complex with two different antagonists—one orthosteric the other allosteric—which functionally cooperate to inhibit CCR2.

•  &  Tracy M. Handel

Review Article | 01 December 2016

Organization and functions of mGlu and GABA B receptor complexes

This Review discusses current knowledge of the structure, function and interactions of the metabotropic glutamate and GABA B receptors and the potential to target receptor subunits for future therapeutic intervention in neurological and mental health disorders.

• Jean-Philippe Pin
•  &  Bernhard Bettler

Brief Communications Arising | 30 November 2016

Drug response consistency in CCLE and CGP

• Mehdi Bouhaddou
• , Matthew S. DiStefano
•  &  Marc R. Birtwistle

Safikhani et al. reply

• Zhaleh Safikhani
• , Nehme El-Hachem
•  &  Benjamin Haibe-Kains

Inside View | 23 November 2016

Inside View: Almirall

Letter | 16 November 2016

High-resolution crystal structure of the human CB1 cannabinoid receptor

The authors report a 2.6 Å resolution crystal structure of the human CB1 cannabinoid receptor trapped in the inactive conformation and bound to the antagonist taranabant.

• Zhenhua Shao
•  &  Daniel M. Rosenbaum

Letter | 13 July 2016

Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation

Stabilization of an active and inactive conformation of the β 2 -adrenergic receptor by allosteric nanobodies reveals differential ligand-dependent regulation of receptor states to control G-protein-coupled receptor activation.

• Dean P. Staus
• , Ryan T. Strachan
•  &  Robert J. Lefkowitz

Article | 04 May 2016

NMDAR inhibition-independent antidepressant actions of ketamine metabolites

The metabolism of ketamine to (2S,6S;2R,6R)-hydroxynorketamine (HNK) is essential for its antidepressant effects, and the (2R,6R)-HNK enantiomer lacks ketamine-related side effects but exerts rapid and sustained antidepressant actions in mice; these antidepressant effects are independent of NMDAR inhibition but require AMPAR activity.

• Panos Zanos
• , Ruin Moaddel
•  &  Todd D. Gould

Letter | 24 February 2016

Structural basis of lenalidomide-induced CK1α degradation by the CRL4 CRBN ubiquitin ligase

Thalidomide and its derivative lenalidomide bind the CRL4 CRBN E3 ubiquitin ligase and target protein substrates for degradation; structural and functional data determined here show that casein kinase 1α and the lymphoid transcription factor Ikaros, the efficacy targets of lenalidomide in two different blood cancers, interact with the CRBN–lenalidomide interface through a β-hairpin destruction motif.

• Georg Petzold
• , Eric S. Fischer
•  &  Nicolas H. Thomä

Letter | 04 November 2015

Resensitizing daclatasvir-resistant hepatitis C variants by allosteric modulation of NS5A

The drug daclatasvir (DCV), which inhibits the hepatitis C virus (HCV) non-structural protein 5A (NS5A), can successfully reduce viral load in patients; here, a combination of DCV and an NS5A analogue is shown to enhance DCV potency on multiple genotypes and overcome resistance in vitro and in a mouse model.

• Jin-Hua Sun
• , Donald R. O’Boyle II
•  &  Min Gao

Spotlight | 18 June 2014

Spotlight on Biotech/Pharma

Letter | 13 November 2013

Antidiabetic effects of glucokinase regulatory protein small-molecule disruptors

Two small-molecule disruptors of the glucokinase–glucokinase-regulatory-protein complex, AMG-1694 and AMG-3969, are identified that decrease blood glucose levels in various models of hyperglycaemic rodents.

• David J. Lloyd
• , David J. St Jean Jr
•  &  Clarence Hale

Article | 12 December 2012

Automated design of ligands to polypharmacological profiles

An automated approach designing drug ligands to multi-target profiles (with a 75% prediction success rate) is experimentally validated by the invention of novel ligands tailored to the complex and physiologically-relevant goal of identifying drugs that can specifically target profiles of multiple proteins.

• Jérémy Besnard
• , Gian Filippo Ruda
•  &  Andrew L. Hopkins

Article | 09 December 2012

High-resolution crystal structure of human protease-activated receptor 1

The X-ray crystal structure of the human G-protein-coupled receptor protease-activated receptor 1 (PAR1) bound to the antagonist vorapaxar is solved, revealing an unusual method of drug binding that should facilitate the development of improved PAR1-selective antagonists.

• Cheng Zhang
• , Yoga Srinivasan

News | 21 November 2012

Drug-pollution law all washed up

EU initiative to clean up waterways faces tough opposition.

• Natasha Gilbert

News | 16 October 2012

Drug firm to share raw trial data

Full disclosure could improve health care and restore trust.

• Declan Butler

News | 11 September 2012

India moves to tackle antibiotic resistance

Drug regulator aims to restrict over-the-counter sales.

• Erica Westly

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Top five research articles of 2020

Despite the significant challenges this year has posed, The Pharmaceutical Journal  has continued to publish high-quality peer-reviewed research.

Our researchers have made a range of investigations — from evaluating pharmacist interventions using the Simpler tool in Malaysia , to a pharmacist-led virtual thiopurine clinic to support people with inflammatory bowel disease and auto-immune hepatitis, here in the UK.

We have some exciting research coming up in 2021, but in case you missed them the first time around, here are the top five most popular research articles of 2020:

5. Misuse of prescription and over-the-counter drugs to obtain illicit highs: how pharmacists can prevent abuse

Use of prescription and over-the-counter drugs for recreational purposes is increasing, and this perspective article collates the existing literature to provide an in-depth overview of the misuse and diversion of a range of drugs with psychoactive potential, including gabapentinoids, antihistamine drugs and loperamide.

4. Effective detection and management of hypertension through community pharmacy in England

Community pharmacists can play a big role in managing hypertension — from the identification of medication-related problems, to providing lifestyle advice. Despite this, they are not routinely involved in structured hypertension management or screening programmes. So, this review summarises the evidence to recommend the roll-out of a community pharmacy-led hypertension management service.

3. Recent advances in the oral delivery of biologics

Oral administration of medicines is often preferred by patients for its convenience, but, for biologics, the gastrointestinal tract poses challenges for administering in this way. This review discusses the advantages and limitations of several novel drug delivery strategies, and highlights the work to be done to put this technology into clinical practice.

2. Immuno-oncology agents for cancer therapy

Immuno-oncology is a novel treatment that works by conditioning the body’s immune cells to recognise and kill cancer cells — combining this treatment with conventional therapies has led to promising improvements in patient outcomes. This review looks at the range of immuno-oncology agents, and how problems such as their toxicity and high cost can be overcome.

1. Investigational treatments for COVID-19

The emergence of COVID-19 resulted in a global research effort to find effective treatment options to relieve healthcare burdens and, ultimately, save lives. In June 2020, this rapid review summarised the clinical trials and treatment evidence at the time.

Check out The Pharmaceutical Journal’ s   ‘Everything you should know about the coronavirus outbreak’ for the latest on this continually evolving situation.

Find the full catalogue of articles in our research section .

Call for submissions

In 2021, The Pharmaceutical Journal will keep adding to the evidence base with review, perspective and research articles. If you have undertaken research into innovations and initiatives that can improve pharmacy services and administration, the pharmacological management of disease, or advances in drug development, please submit your article for consideration by email to: [email protected]

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